COMMENTARY ON THE STUDY,
MICHELS et al. 2007
(note: this same data was used to "show" that HRT was totally safe...
until two double blind studies on HRT had to be halted because the women
taking HRT not only had a 40 percent greater chance of stroke, thrombosis
and heart attack but at least a 25 percent greater chance of BREAST
cancer. So much for epidemiological DATA DREDGE studies - great for
media spin but NOT science!)A new study by Karin Michels and her
colleagues on the link between abortion and breast cancer is seriously
flawed, said the Coalition on Abortion/Breast Cancer. They found almost no
increase in risk - a 1.01 hazard ratio for women who had one or more
abortions. [1]
"We call on journalists to challenge Michels et al. to conduct a proper
study that allows sufficient follow-up time between exposure to abortion
and the development of breast cancer," said Karen Malec, president of the
coalition. "Ask the researchers whether the person who smokes cigarettes
today will develop lung cancer next month or whether it takes years to
develop the disease."
Michels et al. collected abortion and breast cancer data during all ten
years of the study. To do the study properly, they should include only
abortions procured up to 1993 and then follow their study subjects for ten
years. At least four other studies [2,3,4,5] in recent years have been
criticized for the same reason. [6,7]
The Journal of American Physicians and Surgeons published a review of 10
prospective studies that are being used to deny an abortion-cancer link.
[6] The study concluded that the 10 studies are significantly flawed and
cannot be used to invalidate the larger body of research showing a link.
No scientist has attempted to shoot down these conclusions.
"This isn't the first time that Harvard Nurses Study researchers [8] have
produced the wrong epidemiological results," said Joel Brind, president of
the Breast Cancer Prevention Institute. "They were wrong about combined
hormone replacement therapy {HRT) reducing the risk of heart attack and
stroke [9], and they're wrong about abortion."
The U.S. National Cancer Institute (NCI) funded the new study, Michels et
al. 2007. Ten years ago, NCI expert Patricia Hartge editorialized against
the abortion-cancer link in the New England Journal of Medicine [10] when
the Danish study [5] was published showing no overall increase in risk.
Even though the Danish study found a statistically significant 89%
increase in risk for women who have abortions after 18 weeks gestation,
Hartge concluded, "In short, a woman need not worry about breast cancer
when facing the difficult decision of whether to terminate a pregnancy."
"So why has the NCI continued to spend millions of dollars to fund studies
on the abortion-cancer link?" asked Malec. "Clearly, its scientists must
either suspect a link or know that it exists."
In their paper, Michels et al. criticized the Danish study [5] for
"possibly introducing nondifferential misclassification" - an allegation
that Brind made ten years ago. [11] Brind criticized the Danish study for
misclassifying tens of thousands of women who'd had abortions as not
having had them. The U.S. Department of Defense helped fund the Danish
study.
Michels et al. suggested that the findings from earlier retrospective
studies reporting an increased risk of breast cancer for women who had an
abortion may have been due to a hypothetical problem called "report bias."
If true, this would mean that the results from the retrospective studies
were artificial. Those who argue that report bias exists say that the only
reason why scientists found an increased breast cancer risk among women
who've had abortions is because more sick women accurately report their
abortion histories than do healthy women.
The problem is that there are no scientists today who claim to have found
credible evidence of the existence of report bias. Moreover, even Karin
Michels' earlier research did not find evidence of its existence.
Michels was a co-author in the study, Lipworth et al. 1995. [12] That
study was published about five months after the study, Daling et al. 1994.
[13] Both studies reported the same risk increase for women who have
abortions - a 51% increase in risk in the former study and a 50% increase
in the latter study.
Lipworth et al. tested for report bias by reviewing Greek literature. They
concluded, "even before legalization, induced abortions were practiced in
Greece with widespread social acceptance. This can be interpreted as
indicating that healthy women then in Greece report reliably their history
of induced abortion." Consequently, Lipworth et al. did not find evidence
of report bias.
Nevertheless, Michels misled Dr. Lawrence Altman, epidemiologist reporter
for the New York Times about the existence of report bias. Lipworth et al.
was submitted for publication on October 20, 1994, but only one week later
on October 27, 1994 Altman interviewed Michels about the study, Daling et
al. She told him "that is a flaw in the design because women who have
breast cancer are more likely to disclose an abortion than women who did
not develop breast cancer." [14]
In their latest paper, Michels and her colleagues speculated that abortion
might protect women from breast cancer. They wrote:
"Because levels of human chorionic gonadotropin rise in the early stages
of human pregnancy, an incomplete pregnancy of short duration might impart
the benefits of a full-term pregnancy and thus reduce the risk of breast
cancer."
Brind, however, scoffed at this idea. He said, "That kind of speculation
is what has been disproved by 50 years of epidemiology."
The study, Michels et al. 2007, focused on the debated breast cancer risk
- whether abortion leaves women with an increased number of
cancer-vulnerable breast lobules. It did not focus on the recognized
breast cancer risk - the loss of the protective effect of a full term
pregnancy.
"Even the NCI agrees that increased childbearing, starting at an early
age, protects women from breast cancer," said Malec. "Legislators have a
moral obligation to require abortion providers to inform expectant mothers
that if they have an abortion, their breast cancer risk will be higher
than it would be if they have a baby. That's settled science."
References:
1. Michels K, Xue Fei, Colditz G., Willett W. Induced and Spontaneous
Abortion and Incidence of Breast Cancer Among Young Women. Arch Int Med
167:814-820.
2. Palmer J, Wise L, Adams-Campbell LL, Rosenberg L. A prospective study
of induced abortion and breast cancer in African-American women. Cancer
Causes and Control 2004;15:105-111.
3. Reeves G , Kan S, Key T, Tjønneland A, Olsen A, et al. Breast cancer
risk in relation to abortion: Results from the EPIC study. International
Journal of Cancer 2006;119;7: 1741 - 1745.
4. Tang NC, Weiss NS, Malone KE. Induced abortion in relation to breast
cancer among parous women: A birth certificate registry study.
Epidemiology 2000;11:177-80.
5. Melbye M, Wohlfahrt J, Olson JH, Frisch M, Westergaard T, Helweg-Larsen
K, Andersen PK. Induced abortion and the risk of breast cancer. N Engl J
Med 1997;336:81-85.
6. Brind J. Induced abortion as an independent risk factor for breast
cancer: A critical review of recent studies based on prospective data. J
Am Phys Surg Vol. 10, No. 4 (Winter 2005) 105-110. Available at:
<http://www.jpands.org/vol10no4/brind.pdf>.
7. Brind J. Letter. Int J Cancer 2007; in press.
8. Stampfer M, Colditz G, Willett W, et al. N Engl J Med. 1991 Sep
12;325(11):756-62.
9. Writing group for the Women's Health Initiative Investigators. Risks
and benefits of estrogen plus progestin in healthy postmenopausal women.
JAMA 2002;288:321-33.
10. Patricia Hartge. Editorial: Abortion, Breast Cancer, and Epidemiology.
New England Journal of Medicine 1997;336:127-128.
11. Brind J, Chinchilli VM. Letter. Induced abortion and the risk of
breast cancer. N Engl J Med 1997;336:1834-1835.
12. Lipworth L, Katsouyanni K, Ekborn A, Michels KB, Trichopoulos D.
Abortion and the risk of breast cancer: a case-control study in Greece.
Int J Cancer 1995;61:181-184.
13. Daling JR, Malone DE, Voigt LF, White E, Weiss NS. Risk of breast
cancer among young women: relationship to induced abortion. J Natl Cancer
Inst 1994;86:1584-1592.
14. Altman L. New study links abortions and increase in breast cancer
risk. The New York Times, October 27, 1994. A-24.
http://www.abortionbreastcancer.com/commentary/070423/index.htm |